Health, Safety and Environment http://www.sjournals.com/index.php/hse <p>The Health, Safety and Environment (HSE) is an open-access journal and free for readers. It is an international journal covering all aspects relating to science, engineering and technology. However our emphasis will be in the fields of Management system, Environmental Sciences, Health and Safety and all related fields. All manuscripts will be subject to peer review before publication. Submitted manuscripts must not be under consideration for publication elsewhere or have already been published.</p> en-US Health, Safety and Environment Editorial http://www.sjournals.com/index.php/hse/article/view/1560 <h3>Editor</h3> Seyed Shamseddin Alizadeh Copyright (c) 2015 Seyed Shamseddin Alizadeh https://creativecommons.org/licenses/by-nc-nd/4.0 2020-11-14 2020-11-14 3 2 TOXICITY AND ANALGESIC STUDIES OF LEAF METHANOLIC EXTRACT OF MAYTENUS SENEGALENSIS (LAM.) EXELL (CELASTRACEAE) http://www.sjournals.com/index.php/hse/article/view/1532 <p>The leaf methanolic extract of&nbsp;<em>Maytenus</em>&nbsp;<em>senegalensis</em>&nbsp;(Lam.) Exell was investigated for toxicity and analgesic effects. Acute toxicity was investigated via intraperitoneal route using mice and rats, analgesic activity was investigated using two models; acetic acid-induced writhing in mice and formalin induced pain in rats. The extract was determined to have LD<sub>&nbsp;(50)</sub>&nbsp;of 1264.91 mg/kg in both mice and rats. It significantly (0.001) inhibited acetic acid-induced writhes in mice at all doses administered (75, 150 and 300 mg/kg) in a dose dependent manner and significantly (0.01) inhibited formalin induced pain in rats, in a non-dose dependent manner. The inhibitory effect observed was higher in the extract compared to the standard used (piroxicam). The results obtained suggested the extract to be relatively toxic in both mice and rats with a dose dependent anti-nociceptive activity.</p> A. A. Murjanatu K. Y. Musa G. Ibrahim M. G. Magaji Copyright (c) 2015 A. A. Murjanatu, K. Y. Musa, G. Ibrahim, M. G. Magaji https://creativecommons.org/licenses/by-nc-nd/4.0 2020-11-13 2020-11-13 3 2 16 20