@article{Iyowamhe Agbanu_Chika Emere_Abdullahi Umar_2016, title={Histopathology of Trypanosoma brucei brucei infected red Sokoto goats experimentally infected and treated with crude ethanolic extract of Terminalia catappa}, volume={5}, url={http://www.sjournals.com/index.php/sjva/article/view/247}, abstractNote={<p>The trypanocidal activity of crude ethanolic extract of&nbsp;<em>Terminalia catappa</em>&nbsp;stem bark was investigated on red sokoto goats experimentally infected with&nbsp;<em>Trypanosoma brucei brucei.</em>&nbsp;15 male goats weighing between 8kg to 10kg were used in this experiment, randomly grouped into 5 groups with three goats per group. Goats in all the 5 groups were infected intravenously with&nbsp;<em>T.b. brucei</em>&nbsp;and after demonstration of parasitaemia Groups 1 to 4 were administered crude ethanolic extract of&nbsp;<em>T.</em>&nbsp;<em>catappa&nbsp;</em>as follows: 50mg/kg orally to group 1, 100mg/kg orally to group 2, 50mg/kg intraperitoneally to group 3 and 100mg/kg intraperitoneally to group 4 while group 5 served as untreated control. All treatments lasted for 7 days. Phytochemical analysis revealed the presence of alkaloids, saponins, terpenoids and steroid. The histopathological findings did not reveal any effect of the extracts on the hearts of all&nbsp;<em>T. catappa&nbsp;</em>treated groups, although, lesions were observed on the spleen, liver, kidney and lung of both treated and untreated (control) group which could be as a result of the infection.</p>}, number={7}, journal={Scientific Journal of Veterinary Advances}, author={Iyowamhe Agbanu, Jocelyn and Chika Emere, Mathew and Abdullahi Umar, Yahaya}, year={2016}, month={Jul.}, pages={105-113} }